在人性化小鼠模型中对艾滋病毒和肺结核共感染的空间转录组分析揭示了特定的转录模式,免疫反应和早期形态变化的信号

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...