产前压力对状小质和相关行为产生值效应
bioRxiv : the preprint server for biology
|February 20, 2025
概括
产前压力会影响后代的神经发育. 高产前压力改变了成年人的行为和大脑细胞,而即使是低压力也会影响胚胎大脑免疫细胞,这表明神经发育障碍风险的门不同.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 发育生物学 发展生物学
背景情况:
- 产前压力是神经发育障碍 (NDD) 的已知危险因素.
- 产前压力可以改变后代的免疫系统和神经免疫细胞.
- 产前压力的程度可能决定后代结果的严重程度.
研究的目的:
- 调查不同严重程度和类型的产前压力对后代纹状结局的影响.
- 为了确定产前压力是否跨越神经发育影响的特定值.
- 检查对成年人的行为,条状小质细胞和母胎免疫接口的影响.
主要方法:
- 在胚胎12-18天期间,CD1小鼠母体暴露于没有压力,低压力 (盐水注射),免疫压力 (素-6注射) 或高压力 (克制+盐水注射).
- 后代在成年后被评估为条状腺依赖行为和条状腺微质形态.
- 分析了母亲的胎盘巨细胞.
主要成果:
- 高度的产前压力显著改变了成人的条形状依赖行为和成人的条形状微质密度.
- 免疫和低产前压力导致成人的行为变化较少.
- 所有压力模型,包括低压力模型,都影响了胚胎条状小质细胞,这表明早期神经免疫影响的门较低.
- 高和低压力模型影响了母亲的胎盘巨细胞.
结论:
- 高度的产前压力对成年人状功能和神经免疫细胞有持续的影响,超过了关键值.
- 所有测试的产前压力模型,即使是低压力,也会影响胚胎神经免疫细胞,这表明早期发育影响的门较低.
- 不同的严重程度和类型的产前压力可能会导致不同的神经发育障碍结果.
相关概念视频
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For gas-phase equilibria, changes in the concentrations of reactants and products can occur with altered volume and pressure. The partial pressure, P, of an ideal gas is proportional to its molar concentration, M.
01:20Stress
When a force is applied on a body, it undergoes deformation. In order to restore the body to its original shape and/or size, an opposite or restoring force is generated within the body. This restoring force is equal to the magnitude of the applied force, but acts in the opposite direction. The amount of this restoring force developed per unit area of the body is called stress. Stress is a tensor quantity and has the SI unit pascal. Stress can be separated into four broad categories depending...
01:22Bearing Stress
Bearing stress refers to the contact pressure between two separate bodies. To visualize this, imagine a bolt thrust through a plate. The bolt applies a force to the plate, which exerts an equal but opposite force back onto the bolt. This force isn't just a singular entity but a compilation of numerous smaller forces distributed across the contact surface between the bolt and the plate.
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01:15Stress: General Loading Conditions
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The shearing force, possessing potential directionality within the plane of the section, is simplified into two component forces running parallel to the x and y axes.
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01:21Plastic Behavior
A material's elastic behavior is characterized by the disappearance of stress once the load is removed, allowing the material to return to its original state. However, when stress surpasses the yield point, yielding commences, marking the onset of plastic deformation or permanent set. This change from elastic to plastic behavior is influenced by the peak stress value and the duration before the load is removed. An intriguing observation occurs when a specimen is loaded, unloaded, and reloaded.
01:23Behavior of Concrete Under Compressive Load
Concrete exhibits specific behaviors under different compressive loads. Understanding this is crucial for understanding its structural integrity. When concrete undergoes uniaxial compression, it tends to develop cracks that run parallel to the direction of the force. These parallel cracks stem from localized tensile stresses that occur perpendicular to the compression direction. Additionally, angled cracks may appear due to the formation of shear planes.
As the concrete specimen fractures under...
As the concrete specimen fractures under...