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Updated: Sep 27, 2026

Forward Genetics Screens Using Macrophages to Identify Toxoplasma gondii Genes Important for Resistance to IFN-γ-Dependent Cell Autonomous Immunity
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在缺乏IFITM3的小鼠中加速适应SARS-CoV-2变种 保持明显的热带和病原体

Parker J Denz, Jonathan L Papa, Matthew I McFadden

    bioRxiv : the preprint server for biology
    |February 20, 2025
    PubMed
    概括

    干扰素诱导的跨膜蛋白3 (IFITM3) 缺乏会加速SARS-CoV-2在新宿主中的适应. 这项研究揭示了IFITM3如何影响病毒进化和病变,影响物种间传播.

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    Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
    The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...