在人类前额叶皮层中异时态层层成熟
Valerie J Sydnor1,2, Daniel Petrie1,2, Shane D McKeon1,2,3
1Department of Psychiatry, University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, PA, USA.
bioRxiv : the preprint server for biology
|February 20, 2025
概括
前额叶皮质 (PFC) 中的大脑可塑性在其各层中发展得不同. 髓成熟遵循深层到表面轴,影响年轻人的神经活动和学习率.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 认知神经科学 认知神经科学
背景情况:
- 人的前额叶皮层 (PFC) 已经扩展了发育可塑性.
- 目前尚不清楚塑性降低是否在PFC层中均发生.
- 在动物模型中,皮层内髓的巩固与可塑性关闭有关.
研究的目的:
- 调查人类PFC中特定层的可塑性时间框架.
- 检查髓成熟在PFC发育中的作用.
- 确定深层和表面的PFC层是否以不同的速度成熟.
主要方法:
- 在年轻人 (10-32岁) 中使用超高场 (7T) MRI 的定量髓成像.
- 髓映射与脑电图 (EEG) 和认知表型的整合.
- 在PFC中沿深到表面轴分析成熟时间.
主要成果:
- 在PFC中的髓成熟遵循深到表面的轴.
- 这个轴在不同的前额皮质区域中有所变化.
- 深层和表面前额叶髓不同地影响神经活动时间尺度,学习速率和处理速度.
结论:
- 跨PFC层的异时成熟是关键的发育机制.
- 这种层特定的成熟平衡了电路稳定性与扩展的神经可塑性.
- 了解这一过程对于认知发展和功能至关重要.
相关概念视频
Lobes of the Cerebrum
506
The cerebral cortex, a critical structure of the brain, is intricately divided into two hemispheres, each consisting of four distinct lobes: occipital, temporal, frontal, and parietal. These lobes function cooperatively to regulate various cognitive and sensory functions, forming the basis of our complex neural capabilities.
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
Frontal lobe
The frontal lobes, located behind the forehead, are the command center of our brain, controlling personality, intelligence, and voluntary muscle movements....
506
Role of Cerebellum and Prefrontal Cortex in Memory
338
The cerebellum, while traditionally associated with motor control, also plays a crucial role in memory, particularly in procedural memory, which involves learning motor tasks that become automatic through repetition. For example, studies have shown that when the cerebellum is damaged, individuals or animals lose the ability to learn conditioned motor responses, such as the conditioned eye-blink response in classical conditioning experiments with rabbits. This study demonstrates the...
338
Lateralization
301
Brain lateralization refers to the division of mental processes and functions between the two hemispheres of the brain, a phenomenon that optimizes neural efficiency and underpins complex abilities in humans. This specialization allows each hemisphere to perform tasks where it has a comparative advantage, facilitating more refined cognitive capabilities across different domains.
301
Cerebrum: Anatomical Overview II
1.5K
Each cerebral hemisphere can be divided into three main regions. The outermost region, the cerebral cortex, is a thin layer (2 to 4 millimeters thick) made up of gray matter, consisting of neuron cell bodies, dendrites, glial cells, and blood vessels. The middle region, or white matter, is primarily composed of myelinated nerve fibers organized into three types of large tracts: association fibers, commissures, and projection fibers. Association fibers connect different areas within the same...
1.5K


