饮食中服用menaquinone-9补充剂不会影响小鼠的骨组织质量或骨矿物质密度
Minying Liu1, Chongshan Liu2,3, Nicolas Cevallos2
1Human Nutrition Research Center on Aging, Tufts University, Boston, MA.
bioRxiv : the preprint server for biology
|February 20, 2025
概括
维生素K的一种形式menaquinone-9 (MK9) 对其对小鼠骨健康的影响进行了研究. 补充剂增加了骨中的MK4,但没有改善骨质或骨密度.
科学领域:
- 生物化学 生物化学
- 骨生物学 骨生物学 骨生物学
- 营养科学 营养科学
背景情况:
- 维生素K对骨健康至关重要,其中基和基-4 (MK4) 是经过充分研究的形式.
- 细菌产生的维生素K形式,如menaquinone-9 (MK9),对于它们对骨的影响不太了解.
- 维生素K依赖的蛋白质是骨组织组成和功能的组成部分.
研究的目的:
- 调查饮食中的menaquinone-9 (MK9) 补充剂对年轻小鼠骨组织质量和密度的影响.
- 确定MK9的代谢命运及其在骨组织内转化为MK4.
- 评估骨MK4度与骨参数之间的关系.
主要方法:
- 年轻的雄性和雌性小鼠在12周内补充了两种不同剂量的MK9 (0.06毫克/千克或2.1毫克/千克的饮食)
- 用乳标记的MK9被给予小鼠子组,以追踪其代谢转化和在骨中的沉积.
- 分析了骨组织质量 (强度,密度,横截面特性) 和肝脏和骨中的MK4/MK9水平.
主要成果:
- 较高的饮食MK9摄入量导致肝脏MK4和MK9水平在两性中显著增加.
- 在骨中检测到的维生素K的主要形式是MK4,其中很大一部分来自标记MK9.
- 在MK9剂量组之间没有观察到腿部组织强度或骨矿物质密度的显著差异.
- 接受更高MK9的雌性小鼠显示了截面面积和惯性瞬间的减少,与雄性不同.
结论:
- 食MK9在骨中转化为MK4,但这种转化不会提高年轻小鼠的整体骨组织质量或密度.
- 虽然MK9影响骨中的MK4水平,但它对骨强度和矿物化的直接影响需要进一步研究.
- 观察到MK9补充剂对骨反应的性别特异性差异,特别是在几何性质方面.
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