相关实验视频

Updated: May 27, 2025

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes
09:12

Modulation of Tau Subcellular Localization as a Tool to Investigate the Expression of Disease-related Genes

Published on: December 20, 2019

6.3K

协同的MAPT突变作为一个平台来发现tau病原发生的修饰剂

Miles R Bryan, Michael Almeida, Carli Opland

    bioRxiv : the preprint server for biology
    |February 20, 2025
    PubMed
    概括

    研究人员开发了一种新的模型来研究阿尔茨海默病 (AD) 中的陶聚合. 热冲击蛋白70 (Hsp70) 被确定为tau聚合的关键驱动因素,提供潜在的治疗点.

    更多相关视频

    An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons05:51

    An In Vitro Model for Studying Tau Aggregation Using Lentiviral-mediated Transduction of Human Neurons

    Published on: May 23, 2019

    5.8K
    In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein09:22

    In Vitro Aggregation Assays Using Hyperphosphorylated Tau Protein

    Published on: January 2, 2015

    18.3K

    相关概念视频

    Microtubule Associated Proteins (MAPs)01:42

    Microtubule Associated Proteins (MAPs)

    Microtubule function and architecture are regulated by an array of specialized proteins called microtubule-associated proteins or MAPs. These proteins are widespread across different organisms and have conserved protein motifs, like the multi-TOG domain for tubulin binding found in the CLASP family of MAPs. Some MAPs are lineage-specific based on their conserved domains. Their functions depend upon the cytoskeletal architecture and cell type they are located within. In-plant cells, a specific...
    4.1K
    Interactions Between Signaling Pathways01:19

    Interactions Between Signaling Pathways

    Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
    Convergence and divergence, and cross-talk between signaling pathways
    Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
    6.2K
    Microtubule Instability02:17

    Microtubule Instability

    Microtubules are hollow cylindrical filaments having a diameter of approximately 25 nm and a length that varies from 200 nm to 25 μm. GTP-bound tubulin subunits form αβ-heterodimers for microtubule assembly. These core building blocks interact longitudinally, polymerizing into protofilaments. The protofilaments then interact with one another through lateral bonding forces to form stable cylindrical microtubules. These cylindrical filaments are dynamic as they undergo repeated...
    4.9K
    MAPK Signaling Cascades01:07

    MAPK Signaling Cascades

    Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
    5.1K
    mTOR Signaling and Cancer Progression03:03

    mTOR Signaling and Cancer Progression

    The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
    The mTOR pathway or the...
    3.7K