相关实验视频
Updated: May 27, 2025

04:36
Murine Superficial Lymph Node Surgery
Published on: May 21, 2012
42.2K
最近的胸膜移民在持续感染期间优先被招募到记忆池中
Zachary T Hilt1, Arnold Reynaldi2, Megan Steinhilber1
1Department of Microbiology and Immunology, Cornell University, Ithaca, NY 14853, USA.
bioRxiv : the preprint server for biology
|February 20, 2025
概括
细胞巨乳病毒 (CMV) 感染通过扩大最近的胸膜移徙者 (RTEs) 进入记忆CD8+T细胞池,导致记忆膨胀. 暴露于CMV的时间决定了哪些RTEs优先长期维持.
科学领域:
- 免疫学 免疫学 免疫学
- 病毒学 病毒学
- T细胞生物学T细胞生物学
背景情况:
- 细胞巨乳病毒 (CMV) 感染诱导"记忆膨胀",在延迟期间在外围组织中持续积累记忆CD8+T细胞.
- 规范这种膨胀CD8+T细胞池的产生和维护的精确机制仍然不完全理解.
研究的目的:
- 为了研究CD8+ T细胞在持续的细胞巨乳病毒 (CMV) 感染期间招募到记忆池中的动态.
- 为了区分新产生的T细胞与成熟的T细胞对记忆池的贡献.
主要方法:
- 利用小鼠细胞巨乳病毒 (MCMV) 作为持续感染的模型系统.
- 使用命运映射小鼠追踪CD8+T细胞的起源和分化.
- 分析了最近的胸膜移民 (RTEs) 和成熟的T细胞之间的表型差异.
主要成果:
- 新生儿暴露于CMV会导致最近的胸膜移徙者 (RTEs) 在记忆CD8+T细胞区内扩张和长期维持.
- 在潜伏阶段产生的成熟CD8+ T细胞对记忆池的贡献最小.
- 在初始感染期间存在的RTEs分化为效应记忆细胞,而后期产生的T细胞更倾向于中央记忆表型.
- 在新生儿和成人CMV感染中观察到RTEs在效应器记忆池中的优先招募.
结论:
- 持续的CMV感染促进了RTE群体的扩大.
- 转基因病毒感染的时间极大地影响了哪一组RTEs (新生儿或成年人) 将被"锁定"在长寿记忆池中.
- 这些发现阐明了慢性病毒感染期间CD8+T细胞记忆形成的关键方面.
相关概念视频
Immunological Memory
516
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
516
Cells of the Adaptive Immune Response
895
The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
895
Cell-mediated Immune Responses
66.7K
Overview
66.7K
T Cell Activation and Clonal Selection
629
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
Naive T cells that have not yet encountered an antigen express two primary CD...
629
Special Features of Adaptive Immunity
728
The adaptive immune system, a crucial component of the overall immune response, offers a highly specialized defense against pathogens. It involves specific cell types and features, enabling it to combat infections effectively and efficiently.
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
728
Development of Immunocompetence
282
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
282

