关于通过离子流动性光谱测量来传达PFAS识别信心的更新指南
Anna K Boatman1, Jessie R Chappel2,3,4, Kaylie I Kirkwood-Donelson5
1Department of Chemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27514, USA.
bioRxiv : the preprint server for biology
|February 20, 2025
概括
全球的污染来自于和多基物质 (PFAS) 是普遍存在的. 本研究建议使用先进的分析方法报告确定的PFAS,提高环境和人类健康研究的一致性.
科学领域:
- 环境化学环境化学
- 分析化学 分析化学
- 毒理学 毒理学 毒理学
背景情况:
- 在全球范围内,在各种矩阵中检测到Per-和多基物质 (PFAS),包括消费品,人体血液和饮用水.
- 非定向分析 (NTA) 越来越多地用于在环境和生物样本中识别PFAS.
- 目前报告发现的PFAS的方法缺乏一致性,阻碍了全面的理解.
研究的目的:
- 调查目前报告LC-GC-IMS-HRMS识别的PFAS可信度水平的做法.
- 建议为PFAS识别提供统一和自动化的信任级指导.
- 将PFAS特有的属性和离子流动性光谱学碰撞截面 (CCS) 值纳入拟议的指导方针.
主要方法:
- 对PFAS信任水平报告的当前实践的审查.
- 开发一个统一的信任水平框架.
- 从离子移动性谱法 (IMS) 结合高分辨率质谱法 (HRMS) 整合PFAS特有的属性和CCS值.
主要成果:
- 在目前的PFAS报告实践中发现了不一致性.
- 提出了一个简化,统一的信任水平指导系统.
- 证明了将CCS值用于增强PFAS识别的实用性.
结论:
- 统一的信任级别系统对于一致的PFAS报告至关重要.
- 拟议的指导方针提高了PFAS识别的客观性和可靠性.
- 该框架支持与PFAS污染相关的更准确的环境和人类健康风险评估.
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