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Updated: May 27, 2025

Chemical Inactivation of the E3 Ubiquitin Ligase Cereblon by Pomalidomide-based Homo-PROTACs
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Published on: May 15, 2019

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PRMT1作为多发性骨髓瘤中关键生存依赖标的治疗潜力

Tabish Hussain, Sharad Awasthi, Farid Shahid

    bioRxiv : the preprint server for biology
    |February 20, 2025
    PubMed
    概括

    多发性髓瘤细胞依赖蛋白质氨酸N-甲基转移酶1 (PRMT1) 才能生存. 用GSK3368715抑制PRMT1可降低细胞增殖和DNA损伤反应,为这种血液性恶性瘤提供潜在的新疗法.

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