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Updated: May 27, 2025

Detection of Heterodimerization of Protein Isoforms Using an in Situ Proximity Ligation Assay
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Published on: October 20, 2018

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通过D2HG和L2HG发现了基拉依赖蛋白-2-Hydroxyglutarylation

Zheng Zhang1, Yi-Kai Liu1, Zhuojun Luo1

  • 1Department of Biochemistry, Purdue University, West Lafayette, IN 47907, USA.

bioRxiv : the preprint server for biology
|February 20, 2025
PubMed
概括

在IDH1/2中导致癌症的突变会导致D-2-基酸盐 (D2HG) 的积累. 这项研究表明,D2HG修改了MRCKA和SLK激酶,抑制了它们的活性和基质酸化.

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