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Updated: May 27, 2025

Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells
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Investigation of the Transcriptional Role of a RUNX1 Intronic Silencer by CRISPR/Cas9 Ribonucleoprotein in Acute Myeloid Leukemia Cells

Published on: September 1, 2019

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库抑制人体细胞中RNA介导的先天免疫反应,以适应灵长类动物特有的Alu扩张

Yimeng Zhu, Angelina Li, Suvrajit Maji

    bioRxiv : the preprint server for biology
    |February 20, 2025
    PubMed
    概括

    库蛋白在人类细胞中对于管理双链RNA (dsRNA) 和防止有害免疫反应至关重要,特别是在灵长类动物进化和Alu元素扩张期间.

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    In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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