在卵细胞转化为卵子细胞的转换过程中发生的线粒会促进物种的不朽性
bioRxiv : the preprint server for biology
|February 20, 2025
概括
成熟的卵子细胞通过OZT (MOZT) 的线粒体灭受损的线粒体,这一过程对胚胎活力和物种连续性至关重要. 这种选择性线粒体质量控制通过防止有害线粒体DNA的继承,确保健康的后代.
科学领域:
- 细胞生物学 细胞生物学
- 发展生物学 发展生物学
- 遗传学 遗传学 是一个
背景情况:
- 线粒体质量对于胚胎发育和长期健康至关重要.
- 卵细胞是细胞的唯一线粒体来源.
- 成熟的卵细胞含有受损的线粒体和功能障碍的线粒体,但防止它们传播的机制尚不清楚.
研究的目的:
- 调查卵细胞阻止受损线粒体传递到胚胎的机制.
- 为了确定在卵细胞成熟期间参与线粒体质量控制的分子参与者.
主要方法:
- 在卵子转化为卵子转化 (OZT) 期间研究了线粒细胞衰变.
- 利用遗传学和分子生物学技术研究了线粒体受体和自途径的作用.
- 评估了MOZT操纵后后代的线粒体健康和胚胎活力.
主要成果:
- 发现了一种新型的线粒过程,称为OZT (MOZT) 中的线粒,在卵子细胞转化为卵子细胞过渡期间触发.
- MOZT需要线粒体分裂,宏自和线粒体受体FUNDC1,但不需要PINK1或BNIP3.
- 卵细胞在对线粒体损伤的反应中调节FUNDC1,促进健康线粒体的选择.
- 失去MOZT会导致受损mtDNA的遗传,后代的生物能量受损,胚胎活力降低,以及人口下降.
结论:
- 在FUNDC1中介的MOZT是维护母体传播期间线粒体健康的关键机制.
- 通过消除受损的线粒体,MOZT确保了胚胎的生存能力,并促进了物种的连续性.
- 这个过程解释了具有突变mtDNA的卵细胞如何产生具有减少有害mtDNA的健康胚胎.
更多相关视频
10:39A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
6.2K
12:36Whole Ovary Immunofluorescence, Clearing, and Multiphoton Microscopy for Quantitative 3D Analysis of the Developing Ovarian Reserve in Mouse
Published on: September 3, 2021
4.5K
相关概念视频
Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
Meiosis vs. Mitosis
52.3K
Cell division is necessary for growth and reproduction in organisms. Mitosis aids cell growth and development by dividing somatic cells. In contrast, meiosis causes the division of germ cells and plays an essential role in sexual reproduction. Due to their unique functional requirements, mitosis and meiosis differ from each other in multiple aspects.
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
Before the start of mitosis and meiosis I, the cell synthesizes DNA, resulting in two homologous copies of each chromosome. DNA synthesis is...
52.3K
Meiosis I
37.5K
Meiosis is the division of a diploid cell into haploid cells forming sperm and eggs in animals through differentiation. Meiosis I is the first stage of meiosis, where the genetic recombination of homologous chromosomes and the reduction of the ploidy level by half occurs.
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
Prophase I is the most extended and complex step of meiosis I characterized by synapsis, chromosome pairing, and recombination of the homologous chromosomes. This process is facilitated by a proteinaceous structure called the...
37.5K
Meiosis II
42.6K
Meiosis II entails cell division and segregation of the sister chromatids, resulting in the production of four unique haploid gametes. The steps for meiosis II are similar to mitosis, except that meiosis II occurs in haploid cells, whereas mitosis occurs in diploid cells.
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
The timing and cell division patterns of meiosis differ between males and females. In male meiosis, the centrosomes are part of the formation of the meiotic spindle. However, in oocytes, including that of humans, Drosophila,...
42.6K
Delivery Pathways to the Lysosome
6.1K
Eukaryotic cells use different mechanisms to eliminate toxic waste obsolete and worn-out substances. Lysosomes play a pivotal role in this, and hence, these substances are carried to the lysosome from other parts of the cell and extracellular space through different pathways. The most elaborately studied pathways to the lysosome are the endocytic pathways.
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
Endocytosis
In endocytosis, the cell membrane takes up macromolecules and particles from the surrounding medium. Clathrin-mediated...
6.1K
Mitochondria
9.7K
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
9.7K
