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Liver Regeneration

Liver Regeneration

The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...

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Updated: May 27, 2025

Bioprinting Cellularized Constructs Using a Tissue-specific Hydrogel Bioink

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Published on: April 21, 2016

基于凝的肝脏组织工程策略

Yu Zhang^1,2, Luofei Li¹, Liang Dong¹

¹National Laboratory of Solid State Microstructures, Department of Physics, Nanjing University, Nanjing 210093, China.

Chem & bio engineering

|February 20, 2025

概括

水凝正在通过为细胞生长提供支架和创建先进的人造肝脏模型来彻底改变肝脏组织工程 (LTE). 这项技术在治疗肝脏疾病和推进再生医学方面具有重大前景.

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科学领域:

生物材料科学生物材料科学
再生医学是一种再生医学.
肝病学肝病学是一种肝病学.

背景情况:

肝脏疾病对全球的健康造成重大负担,需要替代肝脏移植的解决方案,因为缺乏捐赠者.
肝脏组织工程 (LTE) 成为一个有希望的替代方案,利用生物相容材料来创建功能性肝脏结构.
模仿肝脏细胞外基质 (ECM) 的水凝对于支持LTE中的细胞活力和功能至关重要.

研究的目的:

审查最近基于水凝的肝脏组织工程策略的进展.
探索各种水凝类型在创建功能性肝脏模型中的应用.
突出水凝在解决肝病治疗和研究方面的挑战方面的潜力.

主要方法:

对脱细胞化肝脏组织水凝的分析.
基于天然聚合物的LTE水凝的研究.
在肝脏应用中检查基于合成聚合物的水凝.
在有机体,3D生物打印和肝脏在芯片系统中对水凝应用的审查.

主要成果:

水凝为体外肝细胞培养和功能提供了合适的微环境.
可调节的水凝特性使复杂的人工肝脏模型的开发成为可能.
基于水凝的平台在肝毒性测试和肝脏再生策略中显示出有效性.

结论:

水凝是多功能生物材料,显著推进了肝脏组织工程.
这些材料为治疗急性肝衰竭和改善肝病管理提供了变革性的潜力.
对水凝应用的进一步研究有望在肝病学中产生重大未来临床和研究影响.