中性粒细胞与淋巴细胞的比例及其与肺结核感染的相关性:基于NHANES数据库的横截面调查
Yunfeng Sheng1, Haibo Hua1, Yanfei Cui1
1Department of Tuberculosis, Hangzhou Red Cross Hospital, Hangzhou, China.
Journal of thoracic disease
|February 20, 2025
概括
中性粒细胞与淋巴细胞比率 (NLR) 与结核感染 (TBI) 风险有负相关性,这表明它可能是一个保护因素. 然而,TBI患者的高NLR水平与增加的死亡风险相关.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 炎症标志物是一种炎症标志物.
背景情况:
- 结核病感染 (TBI) 构成一个重大的全球健康挑战,需要早期检测和治疗.
- 炎症是TBI病原体的组成部分,但作为炎症标记物的中性粒细胞与淋巴细胞比率 (NLR) 在TBI风险方面仍未得到充分研究.
- 本研究利用国家健康和营养检查调查 (NHANES) 数据库来调查NLR与成人TBI风险之间的关联.
研究的目的:
- 探索中性粒细胞与淋巴细胞比率 (NLR) 与成人结核感染 (TBI) 风险之间的关联.
- 确定TBI诊断和治疗的潜在新生物标志物.
- 调查NLR和TBI风险之间的关系,解决当前研究中的差距.
主要方法:
- 采用横截面设计,将NHANES (1999-2000年和2011-2012年) 的数据与TBI作为依赖变量和NLR作为独立变量汇集在一起.
- 包括2,433名参与者 (391名TBI,2,042名非TBI),分析了包括BMI,吸烟,饮酒和NLR在内的人口和临床因素.
- 使用加权后勤回归,分层和子组分析,受限立方线 (RCS) 和卡普兰-梅尔 (K-M) 生存曲线来建模和分析NLR-TBI关系.
主要成果:
- 在NLR和TBI风险 (OR<1,P<0.05) 之间发现了显著的负相关性,受糖尿病的影响 (P相互作用=0.049).
- 这种负面关联在男性和高血压患者中尤为明显 (P<0.05).
- RCS分析表明线性关系 (P-非线性=0.9561),NLR>1.899表明具有保护作用. 通过K-M曲线,高的NLR (>2.328) 与TBI患者的死亡率增加有关.
结论:
- 中性粒细胞与淋巴细胞的比率 (NLR) 显示出与结核感染 (TBI) 风险有显著的负相关性.
- 在TBI患者中,较高的NLR水平与较差的结局和增加的死亡率有关.
- 在评估TBI风险和患者预后方面,NLR可以作为一个有价值的生物标志物.
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