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临床分析和病例系列报告关于自身免疫性质纤维状酸性蛋白质星细胞病变,呈现自主功能障碍

Xiao Ke Wu¹, Guojie Zhai², Jin Ru Zhang²

¹Suzhou Ninth People's Hospital, Suzhou, China.

Frontiers in neurology

|February 20, 2025

概括

自主功能障碍,包括膀和胃肠道问题,在自身免疫性质纤维酸性蛋白星细胞病变 (GFAP-A) 中很常见. 较高的脑脊液蛋白质水平与这些患者的预后更差相关.

科学领域:

神经学神经学
免疫学免疫学免疫学
自主神经科学自主神经科学

背景情况:

越来越多的人认识到自身免疫性状纤维酸性蛋白星细胞病 (GFAP-A),但自主功能障碍往往被忽视.
GFAP-A可以显著影响自主神经系统,导致各种临床表现.

研究的目的:

综合分析GFAP-A患者自主功能障碍的临床特征,实验室发现和成像指标.
阐明在GFAP-A.中自主症状的流行率和预后.
为个性化诊断和治疗策略提供基础.

主要方法:

对三个自主参与的GFAP-A案例进行了回顾性分析.
广泛的文献审查确定了39个额外的病例,总计42名患者.
对临床数据,生物标志物和成像的全面分析.

主要成果:

最常见的自主功能障碍是膀 (98%) 和胃肠道 (43%) 问题.
其他症状包括心率变化 (10%),异常出汗 (5%),血压波动 (2%).
脑脊液蛋白质水平与预后有关,较高水平表明结果更差.

结论:

膀和胃肠道功能障碍是GFAP-A.中自主问题的主要表现.
临床医生必须密切关注GFAP-A患者的自主症状,因为它们的预后影响.

关键词:

在GFAP-A中.自免疫性质纤维化酸性蛋白质天体细胞病变.自主功能障碍的自主功能障碍.预后预后预后尿功能障碍尿功能障碍尿功能障碍

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