在早产的人类胎盘中检测到高的微型和纳米塑料.
Michael Jochum1, Marcus Garcia2, Alexandra Hammerquist1
1Department of Obstetrics and Gynecology, Baylor College of Medicine and Texas Children's Hospital.
Research square
|February 20, 2025
概括
微塑料和纳米塑料 (MNP) 在早产婴儿的胎盘中发现的度更高. 特定的MNP如PVC和PC与早产有关,这表明潜在的健康风险.
科学领域:
- 环境健康 环境健康
- 生殖科学 生殖科学
- 毒理学 毒理学 毒理学
背景情况:
- 微型和纳米塑料 (MNP) 在环境,饮食和生物样本中越来越多地被检测到.
- 人们越来越担心MNP暴露对健康的潜在影响.
- 在此之前,没有研究过MNP暴露与早产 (PTB) 之间的关系.
研究的目的:
- 量化来自满期和早产的胎盘中的MNP聚合物.
- 调查MNP度与PTB之间的关联.
- 确定与PTB和不良妊娠结果相关的特定MNP类型.
主要方法:
- 在胎盘组织中12种MNP聚合物的定量测定,来自87例满期和71例早产.
- 使用热解气色谱/质谱 (Py-GC/MS) 进行MNP分析.
- 采用后勤回归来确定PTB的独立预测因子.
主要成果:
- 累积的MNP度在PTB的胎盘中明显高 (28%) 与到期分娩相比.
- 在PTB胎盘中观察到高水平的聚乙烯 (PVC),聚乙烯二甲 (PET),聚氨 (PU) 和聚碳酸 (PC).
- PET,PU和PC与妊娠年龄和出生体重相反相关;PVC和PC被确定为PTB的独立预测因素.
结论:
- 这项研究提供了第一个证据,将胎盘中的MNP存在与早产联系起来.
- 特定的MNP,包括PVC和PC,与PTB的风险增加有关.
- 研究结果强调,需要在怀孕期间尽量减少MNP暴露,以减轻对母亲和新生儿健康的风险.
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