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Updated: May 27, 2025

Pre-Conditioning the Airways of Mice with Bleomycin Increases the Efficiency of Orthotopic Lung Cancer Cell Engraftment
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一个经 bronchoscopically 诱导的转基因肺癌猪模型的人类可翻译性的表征

Jussuf Kaifi1, Kirtan Joshi1, Kanve Suvilesh1

  • 1University of Missouri.

Research square
|February 20, 2025
PubMed
概括

一个新的Oncopig模型通过支气管镜诱导有效地模仿人类肺癌 (LC). 这种免疫能力强的猪模型显示了与人类LC的显著转录组重叠,为未来的研究提供了高临床可翻译性.

关键词:
在Oncopigig上使用.大型动物癌症模型猪肺癌模型的模型转基因癌症模型转基因癌症模型翻译性癌症研究

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Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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