食脂肪对肠道微生物组成和功能在卵巢癌中的影响
Mariam M AlHilli1, Naseer Sangwan1, Alex Myers1
1Cleveland Clinic.
Research square
|February 20, 2025
概括
性饮食和高脂肪/低碳水化合物饮食通过减少肠道微生物群多样性,加速了卵巢癌的生长. 在小鼠中,低脂肪/高碳水化合物饮食支持更健康的微生物群和较慢的瘤进展.
科学领域:
- 在瘤学瘤学.
- 微生物学 微生物学
- 营养科学 营养科学
背景情况:
- 肠道微生物组 (GM) 在调节炎症,免疫反应和癌症进展方面发挥着至关重要的作用.
- 饮食干预,如性 (KD) 和高脂肪/低碳水化合物 (HF/LC) 饮食,可以显著影响转基因成分和宿主代谢.
研究的目的:
- 研究KD和HF/LC饮食对转基因变异和瘤生长的影响.
- 为了将这些效应与低脂肪/高碳水化合物 (LF/HC) 饮食相比较,在高度血清性卵巢癌 (EOC) 的综合性小鼠模型中.
主要方法:
- 30只具有EOC (KPCA细胞) 的雌性C57BL/6J小鼠被随机分为KD,HF/LC和LF/HC饮食组.
- 使用体内成像监测瘤生长.
- 便样本通过16S rRNA和猎枪元基因组测序来分析,以评估转基因生物的分类构成和代谢功能.
主要成果:
- 与LF/HC饮食相比,KD和HF/LC饮食显著加速了EOC瘤的生长.
- 在KD和HF/LC群体中,转基因多样性减少,与瘤生长增加相关.
- 特定的微生物种群和代谢途径 (例如,聚胺生物合成,脂肪酸氧化) 在饮食组之间存在差异.
结论:
- 在EOC中,饮食显著影响肠道微生物群和瘤代谢.
- 饮食干预与癌症进展有着复杂的关系,需要进一步研究治疗潜力.
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