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Updated: May 27, 2025

Thermostabilization, Expression, Purification, and Crystallization of the Human Serotonin Transporter Bound to S-citalopram
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维拉佐对血清素转运体双重结合模式的结构基础

Iris E Kalenderoglou1, Andreas Nygaard1, Caleb D Vogt2

  • 1Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.

Research square
|February 20, 2025
PubMed
概括

胺转运体 (SERT) 是抗抑郁药的目标. 这项研究揭示了维拉佐是如何与SERT结合的,确定其内醇环对于高亲和度和独特的结合特性至关重要.

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