在COVID-19疫苗接种后的心肌梗塞患者心血管和肝脏变化的评估
Mohamed Gamil Mehanna1, Thamir Mahmoud Eid1, Badr Abdullah Maarof2
1Department of Biochemistry, Faculty of Science, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Current vascular pharmacology
|February 20, 2025
概括
接种COVID-19疫苗可能与心肌梗塞 (MI) 和肝脏压力有关. 这项研究分析了沙特阿拉伯的102名首次心脏病发作患者,发现疫苗接种后心脏和肝脏生物标志物升高.
科学领域:
- 心脏病学 心脏病学
- 疫苗学 疫苗学 疫苗学
- 肝病学 肝病学是一种肝病学.
背景情况:
- 虽然COVID-19疫苗接种活动减少了严重疾病的发生,但也引发了人们对心血管系统影响的担忧,特别是心肌梗塞 (MI).
- 新出现的证据需要对疫苗接种后的潜在不良事件进行调查.
研究的目的:
- 调查COVID-19疫苗接种与沙特阿拉伯心肌梗塞 (MI) 发生率之间的关联.
- 在接种疫苗后,分析心血管和肝脏生物标志物.
主要方法:
- 分析了沙特阿拉伯102名首次心脏病发作患者的队列.
- 数据包括患者的人口统计,血型和心脏压力指标 (BNP,脉率,缩血压).
- 疫苗接种后评估了心脏损伤 (CK-MB,CPK) 和肝功能 (AST,ALT, bilirubin) 的生物标志物,控制了混因素.
主要成果:
- AST (121.65 U/L) 和ALT (133.63 U/L) 的升高水平表明疫苗接种后肝脏有显著的压力 (p < 0.01).
- 与女性相比,男性的AST,ALT和胆红素水平较高 (p <0.05).
- 升高的CK-MB (58.05 IU/L) 和CPK (313.86 mcg/L) 表明心肌有显著的损伤 (p < 0.05).
结论:
- 研究结果表明,COVID-19疫苗接种与心血管事件 (包括心肌梗塞) 之间存在潜在联系.
- 该研究强调了在评估疫苗安全时考虑个体健康状况的重要性.
- 心血管和肝脏影响在接种疫苗的背景下需要进一步调查.
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