尼斯塔丁:β-环氧化和氧化:β-环氧化粘膜水凝,用于特定地点的口腔应用
Amanda Aparecida Maia Neves Garcia1, Juliana Aenishanslin2, Carolina Yoshi Campos Sugio1
1Department of Prosthodontics and Periodontics, Bauru School of Dentistry, University of São Paulo (USP), Bauru, Brazil.
Therapeutic delivery
|February 20, 2025
概括
新的粘粘液水凝结合nystatin和chlorohexidine与β-cyclodextrin显示增强的保留和药物释放治疗口腔病变.
科学领域:
- 制药科学 制药科学
- 生物材料科学 生物材料科学
背景情况:
- 开发粘膜水凝,以增强药物输送.
- 采用β-环氧德克斯复合物来提高药物的溶解性和释放性.
研究的目的:
- 为了开发和分析nystatin:β-cyclodextrin和chlorhexidine:β-cyclodextrin粘膜粘合水凝.
- 评估它们的粘粘性,药物释放动力学和抗真菌活性.
主要方法:
- 使用体外和体外分析对水凝的表征.
- 对抗Candida albicans的抗真菌活性的评估.
- 病理学研究和猪口腔粘膜保留试验.
主要成果:
- 水凝在猪口腔粘膜上显示出很高的粘合性和保留性 (83.37%).
- 与非复杂药物相比,复杂药物的释放率是复杂药物的1.5-4.0倍.
- 针对Candida albicans,观察到显著的抑制百分比 (88.87%的尼斯塔丁,91.57%的赫西丁).
结论:
- 含包括复合体的粘膜水凝为治疗口腔病变提供了一种有前途的方法.
- 在治疗部位增强的保留可以提高治疗疗效.
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