结肠直肠神经内分泌新生瘤的发病率趋势和相对存活率:使用德国癌症注册数据的基于人口的研究
Lennart Möller1,2, Andras Szentkirályi1, Christine Eisfeld1
1Cancer Registry of North Rhine Westphalia, Bochum, Germany.
International journal of cancer
|February 20, 2025
概括
结直肠神经内分泌瘤 (NENs) 的发生率,包括神经内分泌瘤 (NETs) 和混合神经内分泌与非神经内分泌瘤 (MiNENs),正在上升,特别是在年轻患者中. 对NET的生存率高于神经内分泌癌 (NEC),直肠NET显示出最好的预后.
科学领域:
- 胃肠病学 胃肠病学
- 在瘤学瘤学.
- 流行病学 流行病学
背景情况:
- 结肠直肠神经内分泌瘤 (NENs) 包括神经内分泌瘤 (NETs),神经内分泌癌 (NECs) 和混合的神经内分泌与非神经内分泌瘤 (MiNENs).
- 了解这些独特的NEN亚型的发病率和生存趋势对于患者管理和公共卫生战略至关重要.
研究的目的:
- 确定德国结肠和直肠NET,NEC和MiNEN的发病率,发病率趋势和相对存活率.
- 分析影响NEN结果的人口和临床病理因素.
主要方法:
- 对来自整个德国人口 (2009-2021) 的12602例NEN病例的综合数据集的分析.
- 年龄标准化发病率,年均百分比变化和5年相对生存概率 (2017-2021) 的计算.
- 根据瘤类型 (NET,NEC,MiNEN) 和位置 (结肠,直肠) 的数据分层.
主要成果:
- NET和MiNEN的总体发病率正在增加,NET的年轻人 (<55岁) 显著增加.
- NEC和MiNEN,以及结肠瘤,在诊断时呈现的更高阶段.
- 对于直肠NET (95.9%) 和结肠NET (81.4%),五年相对存活率很高,但对于NEC (结肠:20.5%,直肠:19.2%) 显着较低.
结论:
- 结肠直肠NEN,特别是NET和MiNEN的发病率上升可能受到增加的查,诊断进步和不断变化的分类系统的影响.
- 瘤类型和位置显著影响预后,与NEC和结肠NEN相关的生存结果较差.
- 需要进一步研究这些趋势的具体驱动因素,并优化诊断和治疗策略.
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