艾滋病毒感染对肝细胞癌的影响:长期预后分析
Yu-Hang Diao1, Fa-Ping Gong1, Yong Cheng1
1Department of Gastrointestinal Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Journal of laparoendoscopic & advanced surgical techniques. Part A
|February 20, 2025
概括
人类免疫缺陷病毒 (HIV) 感染与早期发病的肝细胞癌 (HCC) 有关. 与没有艾滋病毒的患者相比,艾滋病毒阳性患者面临着HCC的较差的长期预后.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 传染性疾病 传染性疾病
- 在瘤学瘤学.
背景情况:
- 肝细胞癌 (HCC) 是一个重要的全球健康问题.
- 人类免疫缺陷病毒 (HIV) 感染对HCC预后的影响需要进一步阐明.
研究的目的:
- 研究艾滋病毒感染对被诊断为HCC的患者预后的影响.
- 分析艾滋病毒感染和不感染的HCC患者的临床特征和生存结果.
主要方法:
- 在PubMed,Embase和Cochrane图书馆进行了系统的文献搜索,截至2024年2月18日.
- 提取数据的元分析,包括连续和分类变量,使用平均差异 (MD) 和几率比率 (OR) 与95%置信区间 (CI).
- 森林地块和漏斗地块被用于分析和出版偏差评估.
主要成果:
- 该研究包括4544名受试者,艾滋病毒阳性患者明显年轻 (MD = -16.13,P <.01).
- 在艾滋病毒阳性和艾滋病毒阴性组之间没有观察到其他临床特征的显著差异.
- 生存分析显示,艾滋病毒阳性HCC患者的长期预后较差 (HR = 0.71,P < .01).
结论:
- 艾滋病毒感染与HCC早期发病有关.
- 艾滋病毒感染者的免疫功能和肝脏健康状况受损,导致HCC预后更差.
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