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在患有糖尿病神经病变的患者中,Sirtuin 1下调和减少维生素D受体表达之间的相关性

Andrea Latini¹, Giada De Benedittis¹, Chiara Morgante¹

¹Department of Biomedicine and Prevention, Genetics Section, University of Rome Tor Vergata, 00133, Rome, Italy.

Acta diabetologica

|February 20, 2025

概括

糖尿病神经病变 (DN) 与2型糖尿病 (T2D) 患者的Sirtuin 1 (SIRT1) 和维生素D受体 (VDR) 表达减少有关. 在VDR中的遗传变异可能会影响其表达水平.

科学领域:

内分泌学在内分泌学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

2型糖尿病 (T2D) 是一种代谢障碍,通常与糖尿病神经病变 (DN) 等并发症有关.
赛尔图因1 (SIRT1) 和维生素D受体 (VDR) 是参与各种细胞过程的蛋白质,包括代谢调节和炎症.

研究的目的:

分析DN和没有DN的T2D患者周围血液中的Sirtuin 1 (SIRT1) 和维生素D受体 (VDR) 表达.
调查影响该群体VDR表达的潜在遗传因素.

主要方法:

招募了51名T2D参与者,对DN进行了神经评估.
在外周血液单核细胞中对SIRT1和VDR的量化mRNA水平.
分析了VDR促进体甲基化状态和rs2228570遗传变异.

主要成果:

与没有DN的患者相比,DN的患者表现出较低的SIRT1和VDRmRNA表达.
在SIRT1和VDR mRNA水平之间观察到正相关性.
在VDR基因中,rs2228570的变异性等位基因与更高的VDR表达有关.

结论:

减少SIRT1和VDR表达水平是T2D患者DN的特征.
相互关联的低VDR表达可能会损害SIRT1转录,影响DN病变发生.
在VDR中的遗传变异可能在调节VDR表达和潜在的DN进展方面发挥作用.

关键词:

糖尿病神经病变是一种神经病变.一个SIRT1系统.维生素D的受体是维生素D的受体.

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