细菌凝血 TBC169 益生菌用于妇科开放手术后肠道功能恢复:一个随机,双盲,安慰剂对照试验
Zhaobo Guan1,2, Zhijiao Zhang1,3, Pengyan Jia1,3
1Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, 99 Longcheng Street, Taiyuan, 030032, China.
International journal of clinical pharmacy
|February 20, 2025
概括
凝血杆菌TBC169显著加快肠道恢复,并降低了妇科开放手术后的并发症率. 这种益生菌在改善患者手术后的结果方面表现有前途.
科学领域:
- 胃肠病学 胃肠病学
- 妇科外科手术 妇科外科
- 微生物组研究 微生物组研究
背景情况:
- 在妇科开放手术后恢复肠道功能是具有挑战性的.
- 细菌凝血 TBC169是一种益生菌,有可能改善肠道运动性和恢复.
研究的目的:
- 评估Bacillus coagulans TBC169在妇科开放腹部手术后增强肠道功能恢复方面的有效性和安全性.
- 为了比较高剂量,常规剂量和安慰剂干预.
主要方法:
- 随机对照试验涉及114名接受开放手术的患者.
- 组:高剂量 (HDG),常规剂量 (CDG) 和安慰剂 (PCG).
- 主要结局:时间到第一次空腹 (TFF);次要结局:TFD,TFBS,DHS,PCR.
主要成果:
- 与PCG相比,TFF在CDG和HDG中明显较短 (P < 0.001).与PCG相比,TFF在CDG和HDG中明显较短 (P < 0.001).
- 在CDG (P <0.05) 和HDG (P <0.001) 中,TFBS降低了.
- 术后并发症的发生率在CDG (P < 0.01) 和HDG (P < 0.001) 与PCG相比明显较低.
结论:
- 凝血杆菌TBC169加速了妇科开放手术后的肠道功能恢复.
- 益生菌显著降低了术后并发症的发生率.
- 没有报告任何不良事件,这表明安全性概况有利.
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