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Updated: Jun 16, 2026

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对AT-9010与弗拉维病毒甲基转移酶的宽谱结合的结构基础

Katerina Krejcova1, Evzen Boura2

  • 1Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, v.v.i, Flemingovo nám. 2, Prague, 16610, Czech Republic.

Archives of virology
|February 20, 2025
PubMed
概括

作为GTP模拟物,AT-9010通过与病毒聚合酶的甲基转移酶域结合来抑制flavivirus复制,而不仅仅是作为链末端. 这种结构的洞察力解释了它对多种orthoflaviviruses的广泛有效性.

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