调查儿童发育回归的诊断收益:系统性审查和元分析
Kirsten Furley1,2,3, Audrey Teo4, Katrina Williams4,5,6,7
1Department of Paediatrics, Monash University, Melbourne, VIC, Australia. Kirsten.Furley1@monash.edu.
Journal of autism and developmental disorders
|February 20, 2025
概括
对于发育衰退的儿童,当神经系统或症状存在时,诊断调查的结果最好. 基因/基因组测试显示出高的诊断产量,为未来的研究提供了标准化的方法.
科学领域:
- 儿科神经学 儿科神经学
- 发育儿科 发育儿科
- 医学诊断 医学诊断 医学诊断
背景情况:
- 儿童的发育回归是一个诊断挑战.
- 识别潜在原因对于有效的管理和干预至关重要.
- 目前的调查方法各不相同,缺乏标准化的协议.
研究的目的:
- 系统地审查和评估对经历发育回归的儿童的诊断调查的结果.
- 为了比较不同临床表现和不同类型的研究的诊断产量.
- 确定哪些调查在诊断发育回归原因方面最有效.
主要方法:
- 进行了对在线数据库 (MEDLINE,EMBASE,CINAHL,PsycINFO,Cochrane) 的系统审查.
- 包括的研究报告了发育回归的儿童的诊断产量.
- 随机效应的元分析使用R软件与元包一起进行.
主要成果:
- 总的诊断收益率因呈现和调查类型而异.
- 患有神经学或症状的儿童显示出最高的诊断产量 (68%).
- 基因/基因组调查的结果为70%,而代谢 (28%),神经生理 (13%),神经成像 (6%) 则为70%.
结论:
- 对发育衰退和神经或症状的儿童进行的调查提供了最高的诊断收益率.
- 遗传/基因组调查在诊断发育回归方面非常有效.
- 虽然在临床上有意义,但结果受到小样本大小的限制,需要进一步研究统计学意义和统一的调查策略.
关键词:
孩子 孩子 孩子 孩子发展回归的发展回归.诊断收益率是一个问题.基因组的基因组学调查 调查 调查代谢过程中的代谢.神经成像是一种神经成像.神经生理学 神经生理学下一代基因测试是下一代基因测试.积极发现的流行率.更多相关视频
05:48The Adventures of Fundi Intervention Based on the Cognitive and Emotional Processing in Attention Deficit Hyperactive Disorder Patients
Published on: June 12, 2020
5.6K
11:29Measuring the Functional Abilities of Children Aged 3-6 Years Old with Observational Methods and Computer Tools
Published on: June 20, 2020
9.0K
相关概念视频
01:15Receiver Operating Characteristic Plot
72
A ROC (Receiver Operating Characteristic) plot is a graphical tool used to assess the performance of a binary classification model by illustrating the trade-off between sensitivity (true positive rate) and specificity (false positive rate). By plotting sensitivity against 1 - specificity across various threshold settings, the ROC curve shows how well the model distinguishes between classes, with a curve closer to the top-left corner indicating a more accurate model. The area under the ROC curve...
72
01:30Oppositional Defiant Disorder
23
A persistent pattern of angry or irritable mood, defiant behavior, or vindictiveness characterizes Oppositional Defiant Disorder (ODD). Symptoms must occur over at least six months, involve interactions with individuals beyond siblings, and meet specific diagnostic criteria to be clinically significant. The disorder affects emotional regulation, social interactions, and behavior, often manifesting early in life and influencing long-term development and functioning.
Diagnostic Criteria and...
Diagnostic Criteria and...
23