在头部和部状细胞癌中模拟生存的8个吸烟指标的表现
Andrew C L Lam1, Katrina Hueniken2, Martha Pienkowski2
1Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
JAMA otolaryngology-- head & neck surgery
|February 20, 2025
概括
吸烟持续时间和日志cig年是模拟头部和部状细胞癌 (HNSCC) 存活率的优越指标. 这些指标更好地预测HNSCC患者的整体存活率 (OS) 与传统的包年相比.
科学领域:
- 在瘤学瘤学.
- 流行病学 流行病学
- 生物统计学 生物统计学
背景情况:
- 吸烟显著增加了头部和部状细胞癌 (HNSCC) 患者的死亡风险.
- 目前在HNSCC生存模型中使用的吸烟指标缺乏最佳关联建模的明确证据.
研究的目的:
- 确定最有效的吸烟指标,以建模HNSCC患者吸烟暴露和整体存活时间 (OS) 之间的线性关联.
- 为了比较各种吸烟指标的表现,包括持续时间和日志卷烟年,与传统的包装年.
主要方法:
- 来自6项临床流行病学研究 (VOYAGER联盟) 的8875名HNSCC患者的回顾性分析.
- 通过使用Cox比例危险模型,对8个吸烟指标 (例如,包装年,持续时间,日志卷烟年) 的线性关联与OS进行评估.
- 基于关联强度 (aHR),线性 (P为趋势),模型匹配 (AIC) 和视觉评估 (spline曲线) 的比较.
主要成果:
- 吸烟持续时间和日志cig-years在HNSCC患者中显示出最强的统计学上显著的线性关联与OS.
- 龙卷-年表现出最好的模型合适 (最低的AIC) 和最线性spline曲线的OS.
- 在各种患者子组和HNSCC子站点中,持续时间和日志年均优于包年.
结论:
- 吸烟持续时间和日志cig-years是优越的指标来建模在HNSCC的OS.
- 这些指标在计算吸烟对存活率的影响方面提供了更好的准确性,而不是包年.
- 研究结果建议将持续时间或日志年纳入HNSCC生存模型,以更精确地评估风险.
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