在美国,饮用地下水中的癌症风险和估计暴露率
Jiajun Luo1,2, Liang Zheng3, Zhihao Jin4
1Department of Public Health Sciences, The University of Chicago Biological Science Division, Chicago, Illinois.
JAMA network open
|February 20, 2025
概括
在一项大型人口研究中,饮用水中的环境暴露与癌症风险显著降低有关. 需要进一步的研究,以了解这种保护作用背后的机制.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 在瘤学瘤学.
背景情况:
- 是一种情绪稳定剂,之前的研究表明它可能会降低双相情绪障碍患者的癌症风险.
- 在一般人群中,环境暴露与癌症风险之间的关联仍然没有研究.
研究的目的:
- 研究饮用地下水中的度与癌症风险之间的关系.
- 评估环境暴露对一般人群的潜在癌症保护作用.
主要方法:
- 来自我们所有人的研究计划的一项大型队列研究 (N=252,178).
- 来自美国地质调查局地下水数据的估计暴露.
- 考克斯比例危险回归模型调整了混因子,分析了癌症发病率在3.6年的中位随访期间.
主要成果:
- 估计较高的暴露量始终与总体癌症风险降低有关.
- 暴露的最高五分位数显示,与最低五分位数相比,癌症风险显著降低 (HR=0.29;95% CI,0.15-0.55).
- 这种关联在各种癌症类型中观察到,在两性中,以及在不同的美国地区.
结论:
- 饮用地下水中的环境暴露与患癌症的风险较低有关.
- 这些发现表明,饮用水中的对公共健康有潜在的益处.
- 需要进一步的研究来阐明这种观察到的关联背后的机制.
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