新型组合免疫疗法和HPV相关癌症患者的临床活动:非随机临床试验
Charalampos S Floudas1, Meghali Goswami1, Renee N Donahue1
1Center for Immuno-Oncology, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland.
JAMA oncology
|February 20, 2025
概括
这项研究表明,针对先进的HPV相关癌症的新组合疗法是安全有效的,特别是针对HPV-16阳性瘤. 它为以前接受免疫检查点阻塞 (ICB) 治疗的患者提供了更好的结果.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 癌症 疫苗 癌症 疫苗
背景情况:
- 在一线治疗后,与人类乳头瘤病毒 (HPV) 相关的晚期癌症的预后不好,治疗选择有限.
- 免疫检查点封锁 (ICB) 已经显示出有效性,但耐药性和进展仍然是重大挑战.
研究的目的:
- 评估一种新型组合治疗先进HPV相关癌症的临床活性和安全性.
- 这种组合包括HPV16型治疗疫苗PDS0101,PDS01ADC (一种联interleukin 12抗体药物) 和bintrafusp alfa (一种抗PD-L1/TGF-β剂).
主要方法:
- 进行了研究人员发起的1/2期非随机临床试验 (NCT04287868).
- 符合条件的患者患有晚期或转移性HPV相关癌症,包括那些对ICB原始或耐药的癌症.
- 治疗包括皮下PDS0101,PDS01ADC (两种剂量表) 和静脉注射的bintrafusp alfa.
主要成果:
- 这项研究包括50名患者;14名是ICB-naive,客观应答率 (ORR) 为35.7%,平均整体存活时间 (OS) 为42.4个月.
- 在ICB耐药患者 (36) 中,ORR为16.7%,平均寿命为15.8个月.
- 在HPV-16-阳性患者 (37) 中,ICB-naive患者 (8) 的ORR为62.5%,并没有达到中位数的OS.
结论:
- PDS0101,PDS01ADC和bintrafusp alfa的组合显示出可接受的安全性和有前途的抗瘤活性.
- 该疗法改善了HPV-16阳性癌症患者的生存状况,包括ICB原始和ICB耐药人群.
- 需要进一步评估这种组合,特别是PDS0101和PDS01ADC与同时抑制PD-L1/TGF-β的组合.
相关概念视频
Cancer Vaccines
325
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
325
Tumor Immunotherapy
463
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
463
Combination Therapies and Personalized Medicine
4.8K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.8K
Targeted Cancer Therapies
7.4K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.4K
Cancer Therapies
7.5K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
7.5K


