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儿童和青少年血压升高和心脏力学:系统性审查和元分析
Andrea Faggiano1, Elisa Gherbesi1, Carla Sala1,2
1Department of Cardio-Thoracic-Vascular Diseases, Foundation IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milano, Italy.
American journal of hypertension
|February 20, 2025
概括
斑点跟踪回声心电图 (STE) 在儿科高血压中揭示了微妙的缩功能障碍,因为全球纵向应变 (GLS) 受到损害,而射出分数 (LVEF) 保持正常. 对于检测高血压儿童的早期变化至关重要.
科学领域:
- 心脏病学 心脏病学
- 儿科 儿科 儿科
- 心声回声扫描 (Echocardiography) 是一种心声回声扫描.
背景情况:
- 关于儿科高血压的左心室 (LV) 机制的证据有限.
- 儿童血压升高可能会影响心脏功能.
- 斑点跟踪回声心脏图 (STE) 是评估LV力学的一个关键工具.
研究的目的:
- 用全球纵向应变 (GLS) 和LV射出分数 (LVEF) 在儿科高血压中对LV系统功能进行元分析.
- 提供有关高血压儿童的 LV 机制的最新信息.
- 确定STE在识别早期心脏功能障碍方面的有用性.
主要方法:
- 在2024年11月之前对主要数据库进行系统的文献搜索.
- 包括报告儿科高血压和对照中的LV机制的研究.
- 随机效应模型用于计算LVEF和GLS的标准化平均差异 (SMD).
主要成果:
- 分析了8项研究 (719名高血压患者,1653名对照患者).
- 两组之间LVEF没有显著差异 (SMD:0.08,P=0.60).
- 在高血压儿童中,GLS显著受损 (SMD: -0.96,P<0.0001) 和全球周围应变.
结论:
- 乳喷射分数 (LVEF) 在儿科高血压中没有检测到早期的缩功能障碍.
- 斑点跟踪回声心电图 (STE) 对于揭露亚临床缩功能障碍非常有价值.
- 在儿科高血压中早期检测心脏变化是必不可少的.
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