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Updated: May 27, 2025

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通过阴离子或芳香替代,增强聚胺酸的骨向性

Xiaoxiong Jin1, Wanying Wang1, Hui Liu1

  • 1Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China.

Biomacromolecules
|February 20, 2025
PubMed
概括

研究人员通过结合新的侧链功能,增强了聚胺酸 (PLG) 的骨准. 这种修改在体内显著改善了骨的向和保留,为骨相关纳米医学提供了更好的聚合物材料.

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Phase II Reactions: Sulfation and Conjugation with α-Amino Acids01:19

Phase II Reactions: Sulfation and Conjugation with α-Amino Acids

Sulfation and α-amino acid conjugation are two critical biotransformation reactions in drug metabolism. Sulfation, a phase II biotransformation reaction, involves adding a polar sulfate group to a drug, enhancing its water solubility and promoting excretion. This process can either co-occur with or occur independently of glucuronidation. Nonmicrosomal sulfotransferase enzymes catalyze the process. The reaction involves 3'-phosphoadenosine-5'-phosphosulfate or PAPS coenzyme...
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