婴儿配方奶粉的加工乳清蛋白成分的蛋白质消化能力和抗炎活性
Yuhui Ye1, Yajing Fang1, Kasper Engholm-Keller1
1Department of Food Science, University of Copenhagen, 1958 Frederiksberg C, Denmark.
Journal of agricultural and food chemistry
|February 20, 2025
概括
热处理提高了乳清奶衍生乳清蛋白缩剂 (SPC) 适用于婴儿配方奶粉的消化能力. 被处理的SPC和常规乳清蛋白缩物 (WPC) 都表现出类似的抗炎生物活性.
科学领域:
- 食品科学 食品科学 食品科学
- 蛋白质化学 蛋白质化学
- 营养科学 营养科学
背景情况:
- 热处理和储存改变了蛋白质结构,可能会影响消化能力和生物活性.
- 乳清蛋白缩物 (WPC) 和脱脂乳制成的 WPC (SPC) 在婴儿配方奶粉中使用.
- 微生物安全需要对这些成分进行热处理.
研究的目的:
- 评估热处理和储存对SPC的影响.
- 将热处理SPC (HT-SPC) 和热储SPC (HTS-SPC) 与参考WPC进行比较.
- 评估蛋白质结构,可消化性和生物活性的变化.
主要方法:
- SPC经过热处理 (80°C,30秒) 和储存 (37°C6周).
- 分析了蛋白质聚合物.
- 实验室婴儿胃和肠道消化模型被使用.
- 通过在THP-1巨细胞中抑制NFκB通路来评估抗炎活性.
主要成果:
- 在HT-SPC,HTS-SPC和WPC中形成的可减少聚合物,但不在控制SPC中.
- 婴儿的肠道状况导致了显著的乳清蛋白水解,与胃状况不同.
- WPC的消化能力高于SPC;热处理提高了SPC的消化能力.
- 来自所有来源的消化的蛋白质显示出可比的抗炎活性.
结论:
- SPC的消化能力不如WPC,但热处理提高了它的消化能力.
- 与WPC相比,SPC的热处理没有改变其抗炎生物活性.
- 研究结果表明,热处理的SPC是婴儿配方奶粉中WPC的可行替代品,在消化能力和生物活性方面.
更多相关视频
10:20In vitro Digestion of Emulsions in a Single Droplet via Multi Subphase Exchange of Simulated Gastrointestinal Fluids
Published on: November 18, 2022
2.4K
05:45Author Spotlight: Process Development for the Spray-Drying of Probiotic Bacteria and Evaluation of the Product Quality
Published on: April 7, 2023
3.2K
相关概念视频
Protein Digestion
Protein digestion begins in the stomach, where the highly acidic environment can easily disrupt protein structure by exposing the peptide bonds of polypeptide chains. After polypeptide chains are broken into individual amino acids by a series of digestive enzymes, the amino acids are transported to the liver via the bloodstream to produce energy.
Hormonal Regulation
Hormones regulate a significant portion of digestion through activation of the neuroendocrine system. The neuroendocrine system of digestion contains many different hormones all with multiple functions that are both, directly and indirectly, involved in digestion.
Overview of Protein Metabolism
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the colonic...
Microbes in Food Production
Microbial fermentation is central to food biotechnology, enhancing flavor, texture, preservation, and stability. Fermentative microorganisms metabolize carbohydrates into organic acids, alcohols, and other metabolites that inhibit spoilage organisms and improve digestibility while contributing distinctive sensory qualities.In baking, amylases naturally present in flour hydrolyze starch into monosaccharides such as glucose, which Saccharomyces cerevisiae ferments anaerobically. Through...
Production of Pharmaceuticals
Industrial insulin production uses genetically engineered E. coli expressing a proinsulin gene controlled by a tryptophan promoter and containing a methionine linker for later cleavage. The cells also carry ampicillin resistance for selective growth. Seed cultures are stored at −80 °C and production begins by thawing a small amount to inoculate starter cultures, which are progressively scaled to a 50,000-L bioreactor. In the bioreactor, E. coli grow in nutrient-rich media under sterile, tightly...
