是的相关蛋白质在人类偶发性结直肠腺瘤中起着致癌作用
Lei Fan1, Xingyi Guo1,2, Mary K Washington3
1Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, 2525 West End Avenue, Nashville, TN 37203, United States.
希波-Yes相关蛋白 (YAP) 显示在早期结直肠癌 (CRC) 发展中具有致癌作用. -YAP (p-YAP) 是识别高风险腺瘤的潜在生物标志物,表明其在CRC进展中的重要性.
科学领域:
- 在瘤学瘤学.
- 分子生物学分子生物学
- 癌症遗传学 癌症遗传学
背景情况:
- 在人类结直肠癌 (CRC) 中,Hippo-Yes关联蛋白 (YAP) 的作用受到争议,关于其功能有相互矛盾的发现.
- 了解YAP在早期CRC中的作用对于开发有效的预防和治疗策略至关重要.
研究的目的:
- 调查YAP在人类偶发性结直肠癌 (CRC) 早期阶段的功能.
- 评估-YAP (p-YAP) 作为晚期腺瘤生物标志物的潜力.
主要方法:
- 在145种零星腺瘤中对p-YAP和APC相关蛋白质的定量测量.
- 在114个腺瘤中进行APC测序,并在326个腺瘤中使用基因表达综合数据分析YAP相关途径.
- 统计分析包括相关性,突变关联,几率比率和生物标志物性能评估.
主要成果:
- p-YAP表达与YAP表达和核β-catenin相关,并且与APC突变有关.
- 过度表达p-YAP强烈预测了晚期腺瘤的几率 (OR=12.62),在调整后保持显著性 (OR=12.31).
- 对于晚期腺瘤,p-YAP表现出高灵敏度 (77.4%) 和特异性 (78.2%),与核β-catenin产生协同作用.
结论:
- 在人类偶发性腺瘤中,YAP起着致癌作用,与Wnt和其他癌症通路相互作用.
- p-YAP是一种潜在的生物标志物,用于识别人类高风险散发性腺瘤.
- 与YAP相关的基因表达揭示了瘤原生途径的丰富,如自和未折叠的蛋白质反应.
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