大菌入侵多索菲拉大脑需要在血脑屏障中对JAK/STAT依赖的MMP激活

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Bente Winkler1, Dominik Funke1, Christian Klämbt1

  • 1Institut für Neuro- und Verhaltensbiologie, Universität Münster, Münster, Germany.

PLoS biology
|February 20, 2025
PubMed
概括

神经炎症通过激活JAK/STAT通路,触发免疫细胞入侵大脑,从而重塑细胞外基质. 这项研究揭示了免疫细胞进入神经系统的保存机制.

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