对处方兴奋剂心血管风险较高的患者进行表征:通过预测分析和数据挖掘技术从健康记录数据中学习
Yifang Yan1, Qiushi Chen1, Rafay Nasir2
1The Harold and Inge Marcus Department of Industrial and Manufacturing Engineering, The Pennsylvania State University, University Park, PA, USA.
Computers in biology and medicine
|February 20, 2025
概括
在患有注意力缺陷/多动障碍 (ADHD) 的成年人中,处方兴奋剂的使用与心血管风险增加有关. 机器学习识别了患者的特征,包括并发症和物质使用,这些特征在处方兴奋剂时表明风险更高.
科学领域:
- 心脏病学 心脏病学
- 精神病学是一个精神病学.
- 数据科学数据科学数据科学
背景情况:
- 对于患有注意力缺陷/多动症障碍 (ADHD) 的成年人来说,增加了兴奋剂的处方,引发了人们对心血管事件风险的担忧.
- 量化这种额外的风险和确定风险患者的个人资料对于安全的处方至关重要.
研究的目的:
- 量化与成年人处方兴奋剂使用相关的心血管事件的额外风险.
- 用机器学习和数据挖掘来描述受兴奋剂治疗不利影响的患者.
主要方法:
- 利用TrinetX (2010-2020) 的成年ADHD患者的电子健康记录.
- 开发和比较机器学习模型来预测一年内心血管风险.
- 雇员协会规则挖掘 (ARM) 以确定具有不良结果的患者的临床特征.
主要成果:
- 该研究包括219,965名成年人,其中102,138人接受兴奋剂治疗.
- 机器学习模型在预测心血管风险方面取得了很高的准确性 (AUC 0.77-0.84).
- ARM确定了关键的风险因素,包括并发症,先前的心血管事件和物质/心理障碍.
结论:
- 集成的预测建模和数据挖掘,以描述使用兴奋剂更高风险的患者.
- 每个年龄组的合并疾病的验证观察清单突出显示了增加的风险.
- 需要对已识别的特征进行外部验证,以指导更安全的兴奋剂处方实践.
更多相关视频
07:31Implementation of a Real-Time Psychosis Risk Detection and Alerting System Based on Electronic Health Records using CogStack
Published on: May 15, 2020
7.0K
08:51Author Spotlight: Integrated Multi-Omics Analysis for Unveiling Multicellular Immune Signatures in Clinical Heart Attack Cohorts
Published on: September 20, 2024
1.1K
相关概念视频
01:18Cardiovascular Drugs: Classification based on Therapeutic Indications
2.0K
Cardiovascular diseases, encompassing a range of conditions, can significantly affect the heart's operations and the overall circulatory system. These conditions impair the heart's ability to pump blood, leading to a deficit in oxygen supply to crucial organs. Anomalies in the heart's electrical system, known as arrhythmias, can cause heartbeats to accelerate or slow down. Usually, heart rates increase during physical activity and decrease while resting or sleeping. However,...
2.0K
01:23Assessment of the Cardiovascular System I: Subjective Data
261
A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
Initial Enquiry
Ask the patient about their primary concern and thoroughly explore all reported symptoms.
Medical History
Investigate past illnesses affecting the cardiovascular system, such as angina, anemia, rheumatic fever, congenital heart disease, stroke, thrombophlebitis, dysrhythmias, varicosities
Inquire about symptoms...
261
01:30Cognitive Enhancers: Cholinesterase Inhibitors and NMDA Receptor Antagonists
95
Cognitive enhancers, also known as "smart drugs," are substances used to enhance memory, mental alertness, and concentration. These can be natural or synthetic and improve cognition in conditions like Alzheimer's disease (AD) and other neurodegenerative diseases. Some common examples include caffeine, amphetamines, methylphenidate, modafinil, arecoline, donepezil, vortioxetine, and piracetam. These enhancers work on the principle of synaptic plasticity and altered circuit function.
95
01:29Stimulants
156
Stimulants are substances that enhance neural activity and elevate dopamine levels in the brain, leading to their highly addictive nature. These drugs include cocaine, amphetamines, MDMA, caffeine, and nicotine, each with distinct mechanisms of action and varied health implications.
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
156
01:12Analysis of Population Pharmacokinetic Data
216
Analysis of population pharmacokinetic data involves studying the behavior of drugs within diverse populations to understand their pharmacokinetic parameters. Traditional pharmacokinetic methods typically involve collecting samples from a few individuals and estimating these parameters. While these methods are commonly used, they have limitations in capturing the variability in drug response among individuals or heterogeneous populations. Population pharmacokinetics is employed to address these...
216
01:19Pharmacovigilance
764
Post-marketing surveillance is a critical component of pharmaceutical regulation, often uncovering unanticipated adverse drug reactions (ADRs) once a drug is widely used over an extended period.
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
This process, termed pharmacovigilance, aims to detect, evaluate, and minimize harmful effects related to medication use. The data collection for pharmacovigilance depends on spontaneous reporting systems, where healthcare professionals or patients voluntarily report suspected ADRs.
In some cases, there...
764