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患有心脏病的狗的抗尿激素度与血清化物之间的关系
A N Harris1, C Hanner1, A Cooper1
1Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, 2015 SW 16th Ave, Gainesville, FL, USA.
概括
抗尿激素 (ADH) 在患有心脏病的狗中升高,即使是在临床前阶段. 这种升高与血清化物水平相反相关,表明非奥斯莫斯释放机制.
科学领域:
- 兽医医学 兽医医学 兽医医学
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 狗的充血性心力衰竭 (CHF) 与电解质失衡有关,特别是电解质度低.
- 非透性抗尿激素 (ADH) 的释放有助于CHF的狗保持水分.
- 了解狗心脏病中的ADH调节对于管理液体和电解质平衡至关重要.
研究的目的:
- 为了比较健康狗的ADH度,患有临床前心脏病的狗和患有心脏不全症的狗.
- 调查ADH度与血清化物水平之间的相关性,血清度以及化物校正的程度.
- 为了探索像安洛迪平和氨酸-氨酸-阿尔多斯特系统抑制剂等药物的ADH水平的影响.
主要方法:
- 在60只狗中测量了血清电解质,血清度和血ADH (20只健康,20只临床前,20只CHF).
- 克鲁斯卡尔-瓦利斯测试用于比较组.
- 多重线性回归分析了ADH和各种临床参数之间的关系.
主要成果:
- 患有临床前心脏病和CHF的狗的ADH度明显高于健康的狗.
- 血清ADH与血清化物和纠正的化物度相反相关.
- 阿姆洛迪平的使用和血清化物水平预测了ADH度,独立于其他因素.
结论:
- 在患有心脏病的狗中存在较高的ADH,不仅仅是在晚期.
- 亚丁和化物之间的反向关系表明,在狗心脏病中,非奥斯莫斯式的亚丁释放.
- 患有心脏病的狗的ADH水平受到除血清度和之外的因素的影响.
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