免疫疗法和细胞疗法用于脏移植患者的癌症
Massini Merzkani1, Rose Mary Attieh2, Kenar D Jhaveri3
1Division of Nephrology, Washington University in St. Louis, St. Louis, Missouri, USA.
American journal of nephrology
|February 20, 2025
概括
接受移植的人面临着由于免疫抑制而增加的癌症风险. 本综述涵盖了那些接受新型癌症疗法,如免疫检查点抑制剂 (ICI) 和CAR-T细胞疗法的人的免疫抑制管理.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 免疫学 免疫学 免疫学
背景情况:
- 移植可以改善末期病的生存率和生活质量.
- 移植后的长期免疫抑制增加了癌症和感染的风险,这是导致死亡的主要原因.
- 移植受体经常被排除在新型癌症疗法的临床试验之外.
研究的目的:
- 审查接受新型癌症治疗的移植患者免疫抑制管理的最新知识.
- 为在接受免疫检查点抑制剂 (ICI),两种特异性T细胞参与剂和仿真抗原受体 (CAR) -T细胞疗法的患者中管理免疫抑制提供指导.
主要方法:
- 对当前研究和临床指导方针的文献综述.
- 综合关于使用和管理免疫抑制在接受脏移植接受者治疗先进的癌症疗法治疗的信息.
主要成果:
- 在接受ICI,双特异性T细胞参与剂和CAR-T细胞疗法的移植患者中管理免疫抑制的更新策略.
- 确定在平衡癌症治疗疗效与移植结果方面的挑战和考虑因素.
结论:
- 有效的免疫抑制管理对于接受癌症治疗的移植患者至关重要.
- 移植脏病学家应与瘤学家和患者在癌症治疗决策中合作,重点关注免疫抑制管理.
- 赋予移植科医生权力有助于综合护理,以改善患者的治疗结果.
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