甜味剂阿斯巴甜通过胰岛素触发的炎症加剧动脉样硬化
Weijie Wu1, Wenhai Sui1, Sizhe Chen1
1State Key Laboratory for Innovation and Transformation of Luobing Theory, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission, Chinese Academy of Medical Sciences and Shandong Province, Department of Cardiology, Qilu Hospital of Shandong University, Jinan 250012, China; Department of Microbiology, Tumor and Cell Biology, Hong Kong Centre for Cerebro-cardiovascular Health Engineering, Karolinska Institute, 171 65 Stockholm, Sweden.
像阿斯巴达姆 (APM) 这样的人工甜味剂会增加胰岛素分泌,通过一种依赖胰岛素的途径加剧动脉样硬化. 准CX3CL1-CX3CR1信号轴可能治疗心血管疾病.
科学领域:
- 心血管科学 心血管科学
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
背景情况:
- 人工甜味剂 (ASW) 的消费与心血管疾病 (CVD) 有关.
- 与ASW相关的心血管疾病的分子机制尚不清楚.
- 阿斯巴甜 (APM) 是一种广泛使用的人造甜味剂.
研究的目的:
- 阐明关联阿斯巴甜 (APM) 消费与心血管疾病 (CVD) 的分子机制.
- 研究胰岛素和特定信号通路在APM诱导的动脉样硬化中的作用.
主要方法:
- 给小鼠和子服用0.15%的阿斯巴甜 (APM),测量胰岛素分泌.
- 利用双边腹膜下阴道切除术 (SDV) 来评估阴道神经的作用.
- 食APM给ApoE-/-小鼠,有或没有胰岛素植入,以研究动脉样硬化.
- 在胰岛素刺激的动脉内皮细胞上进行全基因组表达分析.
- 在单细胞/巨细胞中产生了Cx3cr1基因的特定删除的小鼠.
主要成果:
- 在小鼠和子中,APM的摄入显著增加了胰岛素分泌.
- 瓦古托米取消了APM诱导的胰岛素升高,突出显示了副交感神经系统的参与.
- 通过一种依赖胰岛素的机制,APM食在ApoE-/-小鼠中加剧了动脉样硬化.
- 胰岛素刺激在动脉内皮细胞中调高了CX3CL1化学激素.
- 在单细胞/巨细胞中Cx3cr1的删除取消了APM加剧的动脉样硬化.
结论:
- 阿斯巴甜 (APM) 消费通过一种依赖胰岛素的机制促进动脉样硬化,该机制涉及副交感激活.
- 内皮CX3CL1-巨CX3CR1信号轴是APM相关动脉样硬化的关键媒介.
- 针对这种信号通路为动脉样硬化心血管疾病提供了潜在的治疗策略.
更多相关视频
07:36Induction of Atherosclerotic Plaques Through Activation of Mineralocorticoid Receptors in Apolipoprotein E-deficient Mice
Published on: September 26, 2018
08:32Studying the Hypothalamic Insulin Signal to Peripheral Glucose Intolerance with a Continuous Drug Infusion System into the Mouse Brain
Published on: January 4, 2018
相关概念视频
Oral Hypoglycemic Agents: Biguanides and Glitazones
Insulin: The Receptor and Signaling Pathways
Oral Hypoglycemic Agents: α-Glucosidase Inhibitors
Acarbose and miglitol are...
Pathophysiology of Diabetes
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility,...
Psychoneuroimmunology: Diabetes and Cancer
Overview of Carbohydrate Metabolism
Glucose transport into cells is facilitated by a family of transport proteins called GLUT (Glucose Transporters). GLUT4 is the primary glucose transporter for insulin-stimulated glucose...
