视觉皮层中的运动和前庭信号允许自我与外部生成的视觉运动分离
Mateo Vélez-Fort1, Lee Cossell1, Laura Porta1
1Sainsbury Wellcome Centre, University College London, London, UK.
Cell
|February 20, 2025
概括
大脑通过视觉,运动和前庭信号将自我运动与世界运动分开. 跑步速度会影响视觉皮层对视觉运动的处理,
科学领域:
- 神经科学
- 感官处理
- 计算神经科学
背景情况:
- 区分自我运动与环境运动对于生存至关重要.
- 大脑中运动源分离的神经机制在很大程度上是未知的.
- 视觉系统在这个过程中的作用,特别是整合运动和前庭输入,需要进一步的研究.
研究的目的:
- 研究小鼠主要视觉皮层 (VISp) 如何整合运动,前庭和视觉运动信号.
- 了解大脑如何根据感官输入区分自身运动与外部运动.
- 阐明运动过程中运动源分离的神经基础.
主要方法:
- 在清醒,头部固定的小鼠体内使用两光子成像.
- 在受控视觉流动刺激期间记录主视野皮层 (VISp) 的神经活动.
- 操纵运动 (跑步) 和被动头部转换以分离主动与被动自动运动线索.
主要成果:
- 初级视觉皮层 (VISp) 根据头部的运动状态 (静止,被动或主动翻译) 来分别表示视觉流.
- 运动 (跑步) 积极抑制与跑步速度一致的视觉转换输入.
- 在运行和翻译速度不一致时,视觉翻译信号在VISp中占主导地位.
结论:
- 运动和前庭信号动态调节皮质中的视觉处理.
- 大脑利用运动和前庭信息的交叉方式整合来建立自我中心的参考框架.
- 这种自我中心的框架对于精确计算动态环境中的自动运动速度至关重要.
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