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双价mRNA或蛋白质COVID-19疫苗的免疫性,反应性和安全性,作为第四剂量给予

Nadia Mazarakis¹, Zheng Quan Toh¹, Eleanor Neal²

¹Infection, Immunity, and Global Health, Murdoch Children's Research Institute, Melbourne, Australia; Department of Paediatrics, The University of Melbourne, Parkville, Australia.

The Journal of infection

|February 20, 2025

概括

与Novavax蛋白质疫苗相比,双价Moderna mRNA疫苗的第四剂量显示出对COVID-19变种的免疫性更高. 然而,Moderna也导致了更频繁的局部和全身反应.

科学领域:

免疫学免疫学免疫学
疫苗学疫苗学疫苗学
传染性疾病传染性疾病

背景情况:

健康的成年人至少在六个月前接种了三剂COVID-19疫苗.
在过去三个月中排除了SARS-CoV-2感染.

研究的目的:

比较第四剂COVID-19疫苗的免疫性,反应性和安全性.
评估双价mRNA (Moderna) 与蛋白质 (Novavax) 疫苗之间的差异.

主要方法:

随机对照试验 (RCT) 参与了澳大利亚496名健康成年人.
参与者接受了Moderna或Novavax作为第四剂量,或者没有额外的剂量 (对照).
同主终点:28天后的抗体水平 (IgG对祖先,Omicron BA.1,BA.4/5,JN.1) 和一周内的反应性.

主要成果:

与Novavax相比,Moderna组对所有测试变种的抗体水平较高 (GMRs从2.11到2.40不等).
与Moderna (89.8%) 与Novavax (73.9%) 相比,观察到局部和全身反应 (1-4级) 的频率更高.
在Moderna (6.2%) 和Novavax (5.1%) 两组中,严重反应 (第3至第4级) 类似.

结论:

现代的第四剂量引起了比Novavax更高的免疫原性,对抗祖先和Omicron亚型,包括JN.1.
与Novavax相比,Moderna疫苗与局部和全身反应性增加有关.
这些发现对未来的COVID-19助推策略有影响.

关键词:

抗体是对抗体的一种.助推器是一个助推器.在 COVID-19 疫情中,第四个剂量是第四剂量.豁免权是一种豁免权.这就是SARS-CoV-2病毒.接种疫苗接种疫苗

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