逆境暴露的发育时间和成年期白物质通道连接性之间的多变量联系
Lucinda M Sisk1, Taylor J Keding1, Emily M Cohodes1
1Department of Psychology, Yale University, New Haven, Connecticut.
Biological psychiatry. Cognitive neuroscience and neuroimaging
|February 20, 2025
概括
早期的逆境影响大脑发育,影响白质连接. 3至8岁之间的逆境与路径变化和成人心理健康有关,特别是创伤后压力症状.
科学领域:
- 神经科学是一个神经科学.
- 发展心理学 发展心理学
- 心理健康研究 心理健康研究
背景情况:
- 早期的逆境是全球性的问题,增加终身心理健康风险.
- 个人对逆境的反应各不相同,这突出了了解神经生物学变化的必要性.
- 逆境暴露的发育时间对于理解它对神经发育和心理健康的影响至关重要.
研究的目的:
- 调查早期逆境时间和白质通道连接之间的关系.
- 为了确定影响大脑结构的逆境的特定发育时期.
- 探索白质变化与成人心理健康结果之间的关联.
主要方法:
- 在107名成年人的数据上使用了稀疏的正规相关性分析.
- 检查了发育逆境暴露和大脑全白质连接之间的共变性.
- 分析了扩散指标,以评估白质通道的完整性.
主要成果:
- 在学前和中幼儿时期 (年龄为4-5岁,8岁) 遭遇的不利情况与改变的白质连接性相关.
- 感觉运动通道显示,随着更高的逆境暴露,连接性增加.
- 皮层-皮层通信通道显示连接性下降.
- 与逆境 (3-8岁) 相关的连接模式与成人创伤后压力症状相关.
结论:
- 逆境会根据功能和发育时间对白质产生不同的影响.
- 在3-8岁之间暴露于不利因素,塑造了白质的发展.
- 白质中的这些发育变化与成人心理健康有关.
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