血托芬与大中性氨基酸比率的急性降低减轻了L-托芬对肠道激素和健康男性能量摄入的影响:一个随机,交叉,探索性试验
Javad Anjom-Shoae1, Maryam Hajishafiee1, Penelope Ce Fitzgerald1
1Centre of Research Excellence in Translating Nutritional Science to Good Health, Adelaide Medical School, University of Adelaide, Adelaide, Australia.
L-三 (Trp) 与大中性氨基酸 (LNAA) 的比例影响食欲. 降低这个Trp/LNAAs比率会降低Trp抑制能量摄入和刺激CCK和GLP-1等食欲激素的能力.
科学领域:
- 营养科学 营养科学
- 胃肠病学 胃肠病学
- 内分泌学 在内分泌学.
背景情况:
- 腹腔内L-三 (Trp) 和L-氨酸 (Leu) 增加了血CCK和GLP-1,减缓了胃的空化并减少了能量摄入.
- Trp与大中性氨基酸 (Trp/LNAA) 的比率与能量摄入相反.
研究的目的:
- 调查血Trp/LNAAs比率的改变如何影响肠道Trp的抑制食欲的作用.
- 描述标准化变化对Trp/LNAAs比率对食欲调节的影响.
主要方法:
- 十二名健康的男性接受了90分钟的内注射盐水,Trp,Trp+Leu (0.22千卡/分钟),或Trp+Leu (0.45千卡/分钟).
- 测量包括血氨基酸,CCK,GLP-1,人类腺压力,以及随后的ad-libitum能量摄入.
- 这项研究采用了随机,双盲,交叉设计.
主要成果:
- 单独使用Trp会持续增加血CCK,GLP-1,并刺激胆道压力,与对照组相比,显著降低能量摄入量.
- 通过Trp+Leu输注,Trp/LNAAs的比率因剂量而有所下降.
- 能量摄入与Trp/LNAAs比率 (R = -0.38;P = 0.02) 相反相关.
结论:
- Trp/LNAAs比率的急性降低与CCK,GLP-1和食欲抑制的Trp诱导刺激受损有关.
- 这些发现突显了Trp食欲调节效应中前后吸收机制之间的复杂相互作用.
- 需要进一步的研究才能充分理解这些关系.
更多相关视频
06:55An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
Published on: December 2, 2015
07:05Behavioral Disturbances: An Innovative Approach to Monitor the Modulatory Effects of a Nutraceutical Diet
Published on: January 3, 2017
相关概念视频
Regulation of Food Intake
Hormonal Regulation
Drugs Affecting GI Tract Motility: Serotonin Receptor Agonists
Metabolic States of the Body: The Absorptive State
Intestinal Phase of Digestion
The arrival of the chyme in the small intestine distends the duodenum, which triggers the enterogastric reflex. This distension...
Major Hormones and Their Functions
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
