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Updated: May 27, 2025

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综合的多omics分析揭示了一种精确治疗策略,该策略针对肝细胞癌中的复制应激,使用WEE1抑制来抑制WEE1

Xing Jia1, Xingxin Zhu2, Shinuo Chen2

  • 1Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Thyroid Surgery Department, Zhejiang Cancer Hospital, Hangzhou 310022 Zhejiang, China; NHC Key Laboratory of Combined Multi-organ Transplantation, Hangzhou 310003, China; Key Laboratory of the Diagnosis and Treatment of Organ Transplantation, Research Unit of Collaborative Diagnosis and Treatment for Hepatobiliary and Pancreatic Cancer, Chinese Academy of Medical Sciences (2019RU019), Hangzhou 310003, China; Key Laboratory of Organ Transplantation, Research Center for Diagnosis and Treatment of Hepatobiliary Diseases, Zhejiang Province, Hangzhou 310003, China.

Journal of advanced research
|February 20, 2025
PubMed
概括

这项研究确定WEE1是肝细胞癌 (HCC) 的合成致命标,通过将氧沙与阿达沃蒂布结合起来. 这种个性化的方法针对HCC的复制应激 (RS),改善患者的预后.

关键词:
在 Adavosertib 中使用.肝细胞癌是肝细胞癌.多个omics的多个omics.氧化酸是一种氧化酸.精准医学是一门精准的医学.复制应激是复制应激的一种.

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