相关实验视频
Updated: May 27, 2025
08:49
A 3D Organotypic Melanoma Spheroid Skin Model
Published on: May 18, 2018
15.6K
低肌肉质量作为晚期黑色素瘤患者预后不良的因素
Kohei Yamakawa1, Yusuke Kurita2, Hideyuki Ishikawa1
1Department of Environmental Immuno-Dermatology, Yokohama City University Graduate School of Medicine, 3-9, Fukuura, Kanazawa-ku, Yokohama, 236-0004, Japan.
Clinical nutrition ESPEN
|February 20, 2025
概括
低肌肉质量与接受免疫检查点抑制剂 (ICI) 的晚期黑色素瘤患者的生存结果更差有关. 这一发现凸显了肌肉质量作为黑色素瘤治疗中的潜在预后因素.
科学领域:
- 在瘤学瘤学.
- 免疫治疗是一种免疫疗法.
- 放射学 放射学是一门学科.
背景情况:
- 免疫检查点抑制剂 (ICI) 改善了晚期黑色素瘤患者的治疗结果.
- 低肌肉质量与ICI在某些癌症类型中的有效性降低有关.
- 在接受ICI治疗的黑色素瘤患者中,低肌肉质量的预后意义需要进一步调查.
研究的目的:
- 研究低肌肉质量对ICI治疗的晚期黑色素瘤患者的整体生存期 (OS) 和无进展生存期 (PFS) 的影响.
主要方法:
- 对76名用ICI治疗的晚期黑色素瘤患者的回顾性分析.
- 根据CT扫描计算的骨肌肉指数 (SMI);低肌肉质量定义为SMI<42cm2/m2 (男性) 或<38cm2/m2 (女性).
- 统计分析以评估低肌肉质量,OS和PFS之间的关联.
主要成果:
- 32名患者肌肉质量低,44名患者肌肉质量正常.
- 较低的肌肉质量与明显较短的中位数OS (7.1与26.6个月;HR 3.12) 和PFS (2.1与14.8个月;HR 3.10) 相关.
- 多变量分析证实,低肌肉质量是不良生存系统 (HR 2.46) 和PFS (HR 3.10) 的独立预测因素.
结论:
- 低肌肉质量是接受ICI治疗的晚期黑色素瘤患者的显著负面预后因素.
- 骨肌肉指数可以作为预测治疗反应和生存的有价值的生物标志物.
- 需要进一步的研究来探索改善这些患者肌肉质量的干预措施.
更多相关视频
07:41A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis
Published on: March 8, 2022
2.4K
08:18Analysis of Lymph Node Volume by Ultra-High-Frequency Ultrasound Imaging in the Braf/Pten Genetically Engineered Mouse Model of Melanoma
Published on: September 8, 2021
2.9K
相关概念视频
01:30Skin Cancer
3.0K
Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
3.0K
01:28Disorders of the Skeletal Muscle
855
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
855