双胞胎出生和血液溶解,肝酶升高和低血小板 (HELLP) 综合征:基于人口的研究
Sofia Nicolls1, Li Qing Wang2, Johanna Koegl3
1Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, BC; Women's Health Research Institute, Vancouver, BC.
概括
双胞胎怀孕显著增加了血液溶解,肝酶升高和低血小板计数 (HELLP) 综合征的风险. 这种风险在双胞胎怀孕的26周后显著升级.
科学领域:
- 产科和妇科 产科和妇科
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 产周研究 产周研究
背景情况:
- 双胞胎怀孕被认为具有更高的孕前率.
- 双胞胎怀孕和HELLP综合征之间的特定关联需要进一步调查.
研究的目的:
- 评估双胞胎怀孕与HELLP综合征之间的关联.
- 为了检查双胞胎与单独怀孕中HELLP综合征的妊娠年龄特定发病率.
主要方法:
- 在不列颠哥伦比亚省 (2008-2020年) 进行了超过524,000例怀孕的回顾性队列研究.
- 使用了不列颠哥伦比亚省产周数据库注册数据.
- 调整了混因子的后勤回归分析,以确定赔率比率.
主要成果:
- 赫尔普综合征发生在每1000例双胞胎怀孕中的21.9例,而每1000例单胎怀孕中的2.6例 (比率8.5).
- 双胞胎怀孕与HELLP综合征的几率增加7.1倍有关.
- 从怀孕26周开始,双胞胎的HELLP综合征发病率急剧上升,而单胞胎的发病率则逐渐增加.
结论:
- 双胞胎怀孕是发展HELLP综合征的重要危险因素.
- 在双胞胎怀孕中,HELLP综合征的风险从怀孕26周开始显著增加.
更多相关视频
相关概念视频
Oogenesis
63.3K
In human women, oogenesis produces one mature egg cell or ovum for every precursor cell that enters meiosis. This process differs in two unique ways from the equivalent procedure of spermatogenesis in males. First, meiotic divisions during oogenesis are asymmetric, meaning that a large oocyte (containing most of the cytoplasm) and minor polar body are produced as a result of meiosis I, and again following meiosis II. Since only oocytes will go on to form embryos if fertilized, this unequal...
63.3K
Teratogenicity
2.3K
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
2.3K


