丸激素替代疗法的好处 在低阴腺男性中
Kelli M Blackwell1, Hannah Buckingham1, Krishna K Paul1
1From the John Sealy School of Medicine, University of Texas Medical Branch, Galveston, Texas (KMB); John Sealy School of Medicine, University of Texas Medical Branch, Galveston, Texas (HB); Department of Emergency Medicine, University of Texas Medical Branch, Galveston, Texas (KKP); Department of Surgery, University of Texas Medical Branch, Galveston, Texas (HU); Department of Emergency Medicine, University of Texas Medical Branch, Galveston, Texas (DVKJ); Department of Internal Medicine, University of Texas Medical Branch, Galveston, Texas (TAB).
替代疗法 (TRT) 在低腺男性中与降低死亡率,心房动,中风和前列腺癌风险有关. 这项研究突出了TRT.
科学领域:
- 内分泌学 在内分泌学.
- 心血管医学 心血管医学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 以低丸激素和症状为特征的低腺症与增加的死亡率有关.
- 替代疗法 (TRT) 旨在恢复生理水平.
- 缺乏与不良健康结果和死亡风险增加有关.
研究的目的:
- 为了比较死亡率,心房动 (AF),中风,心肌梗塞 (MI) 和前列腺癌的发病率.
- 为了评估接受TRT与不接受TRT的低腺男性的结局.
主要方法:
- 从TrinetX数据库 (2005-2020年) 中对被删除的EMR数据进行了回顾性分析.
- 包括40至80岁的被诊断患有阴性腺体缺陷症的男性,比较TRT与没有TRT的队列.
- 倾向匹配用于平衡混因素并减少三年结果分析中的偏差.
主要成果:
- TRT组的死亡率显著降低 (3.1%与3.6%,P<.001).
- 在TRT组中降低了AF (3.6%与4.0%,P<.001),中风 (1.6%与1.8%,P<.011) 和前列腺癌 (1.9%与2.9%,P<.001) 的风险.
- 在这些结果中,TRT的相对风险 (RR) 表示了TRT的显著好处.
结论:
- 在低腺男性中,TRT的使用与死亡率,AF,中风和前列腺癌的适度较低率有关.
- 由于数据库的局限性,可能会低估某些结果 (中风,前列腺癌,心血管疾病).
- 了解TRT的风险和益处对于指导临床实践至关重要,因为其使用量增加.
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