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在状细胞疾病中对2型糖尿病的查和诊断

Bria Carrithers¹, Rachel Klein², Fernando Ovalle²

¹From the Department of Internal Medicine, University of Alabama Birmingham School of Medicine, Birmingham, AL (BC); Division of Academic General Pediatrics, University of Alabama Birmingham School of Medicine, Birmingham, AL (RK); Division of Endocrinology, Diabetes, and Metabolism, University of Alabama Birmingham School of Medicine, Birmingham, AL (FO); Division of Hematology and Oncology, University of Alabama Birmingham School of Medicine, Birmingham, AL (RK, JK). bria.carrithers@yale.edu.

Journal of the American Board of Family Medicine : JABFM

|February 20, 2025

概括

在状细胞疾病 (SCD) 中精确的2型糖尿病 (T2DM) 查需要特定的方法. 建议在SCD患者的T2DM查中使用禁食血糖,从35岁开始.

科学领域:

内分泌学在内分泌学.
血液学血液学血液学
内部医学内部医学

背景情况:

在状细胞病 (SCD) 患者中诊断2型糖尿病 (T2DM) 是由于血红蛋白A变异而具有挑战性的.
精确的查对于预防这一群体的严重发病率和死亡率至关重要.
初级保健医生需要指导T2DM查和SCD患者的诊断.

研究的目的:

综合对SCD患者T2DM医学诊断标准的建议.
为临床医生提供基于证据的指导方针.
为了解决这个独特的患者群体的诊断复杂性.

主要方法:

进行了全面的文献审查.
搜索的数据库包括PubMed,糖尿病医疗标准,USPSTF和NIDDK.
选择了2022年12月28日至2023年3月15日发表的研究,重点关注T2DM和SCD.

主要成果:

五篇文章符合SCD中T2DM门诊查和诊断的纳入标准.
建议以禁食血葡萄糖为标准查方法,从35岁开始.
由于效用有限,不建议在患有SCD的个体进行T2DM查或诊断时使用HbA1c,果糖胺和糖性蛋白.

结论:

目前仅有有限的研究可用于诊断SCD患者的T2DM.
禁食血葡萄糖是SCD中T2DM查的推标准.
通过禁食血葡萄糖早期诊断可以预防与这两种疾病相关的宏血管和微血管并发症.

关键词:

内分泌学在内分泌学.家庭医学家庭医学家庭医学果糖胺是一种果糖胺.血液学血液学血液学内部医学内部医学状细胞疾病状细胞疾病 2 型糖尿病 2 型糖尿病

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