年龄对BCG治疗反应的影响
J Patrick Tavelli1, Rainjade Chung2, Ketty Bai1
1Columbia University Vagelos College of Physicians and Surgeons, New York, NY.
Urologic oncology
|February 20, 2025
概括
与年轻患者相比,接受非肌肉侵入性膀癌 (NMIBC) 治疗的老年患者 (70岁以上) 没有出现复发,进展或癌症特异性死亡风险增加.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 卡尔梅特-格林菌 (BCG) 是用于治疗非肌肉侵入性膀癌 (NMIBC) 的标准免疫疗法.
- 人们担心,由于与年龄相关的免疫力下降,老年人可能会降低BCG疗效.
- 以前的研究表明,年龄可能不会影响BCG治疗的NMIBC患者的生理结果.
研究的目的:
- 为了验证NMIBC中关于晚年和BCG治疗结果之间的关联的发现.
- 为了调查70岁以上的患者在BCG治疗后是否经历了较年轻患者相比更糟糕的结果.
主要方法:
- 对473名接受BCG治疗的NMIBC患者 (2000-2023) 的回顾性分析.
- 患者分为两个年龄组:≤70岁和>70岁.
- 细灰竞争风险生存分析评估了高度复发 (HGR),进展和癌症特异性死亡率 (CSM).
主要成果:
- 49%的患者年龄≤70岁,51%的患者年龄>70岁.
- 年龄组之间的基线特征没有显著差异.
- 患者>70没有显著增加HGR (HR 0.77),进展 (HR 1.17) 或CSM (HR 1.12).
结论:
- 在接受BCG治疗的NMIBC患者中,高级年龄 (>70) 与更糟糕的瘤结局无关.
- 在患有NMIBC的老年人中,BCG免疫疗法仍然有效.
- 研究结果支持在NMIBC治疗中使用BCG,无论患者的年龄如何.
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