在原发性黑色素瘤中瘤透淋巴细胞与更好的预后有关
Steven L Morrison1, Gang Han2, Faith Elenwa2
1University of Wisconsin School of Medicine and Public Health, Madison, WI, USA.
American journal of surgery
|February 20, 2025
概括
瘤透淋巴细胞 (TIL) 与黑色素瘤患者更好的生存结果密切相关. 这一发现表明,TIL可以帮助预测患者的预后,并指导治疗决策.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
背景情况:
- 瘤透淋巴细胞 (TIL) 在黑色素瘤的预后意义仍然不清楚.
- 进行了一项大型多中心研究,以调查TIL和患者存活率之间的关联.
研究的目的:
- 评估瘤透淋巴细胞 (TIL) 与黑色素瘤患者的存活率之间的关系.
- 确定TIL是否可以帮助辅助治疗决策的风险分层.
主要方法:
- 利用了来自Sentinel淋巴结工作组数据库 (1993-2024) 的数据.
- 分析了TIL存在 (缺席,非急性,急性) 并与黑色素瘤特异性存活率 (MSS),整体存活率 (OS) 和无复发存活率 (RFS) 相相关.
主要成果:
- 在4957名患者中,有80.2%患有TIL.
- 在MSS,OS和RFS中,TIL的存在是显著的预后因素 (p < 0.0053).
- 与非急性TIL相比,急性TIL与改善生存结果的相关性更强,特别是在阳性哨兵淋巴结患者中.
结论:
- 瘤透淋巴细胞 (TIL) 是黑色素瘤生存的强有力的预测因素.
- TIL评估对分层患者风险和告知辅助治疗选择有价值.
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